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Public release date: 3-Jul-2012[ | E-mail |
Share ] Contact: Concepcion Ruiz Rodriguez
crr@ugr.es
34-958-243-497
University of Granada
A study conducted at the University of Granada hasdemonstrated that ibuprofen a non-steroidal anti-inflammatory drug (NSAID) has beneficial effects on bone repair after afracture or following bone surgery.
In vitro tests demonstrated that unlike other NSAIDs when a therapeutic dose of ibuprofen is administered, it has no negative effects on the proliferation and synthesis of obsteoblast osteocalcin, a cell which is directly involved in the formation and regeneration of bones.
Osteoblast cells are bone cells that synthesize the bone matrix. Consequently, osteoblasts play a major role in bone development, growth, maintenance and repair.
Positive Results
In an article recently published in the prestigious Journal of Bone and Mineral Metabolism, the University of Granada researchers report the positive effects of ibuprofen on bone repair. The researchers are members of the research group BIO277, which studies the effects of different pharmacological and non-pharmacological therapies on obsteoblast cells.
The primary author of this article, Concepcin Ruiz Rodrguez, a professor at the University of Granada Nursing Department states that "up to date, we had little information on the effects of ibuprofen on osteoblast cells". The University of Granada study demonstrates that a therapeutic dose of ibuprofen (5-25m.) does not inhibit the proliferation and synthesis of osteocalcinin the MG-63 cell line. However, when higher doses are administered (>25 m.) they may activate other cells, which might explain theexpression of membrane markers and the decrease in the phagocytic capacity.
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Reference: This article is available at: http://www.ncbi.nlm.nih.gov/pubmed/22543821
Contact: Concepcin Ruiz Rodrguez. University of Granada Department of Nursing. Phone Number: +34 958 243 497. E-mail: crr@ugr.es
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 3-Jul-2012[ | E-mail |
Share ] Contact: Concepcion Ruiz Rodriguez
crr@ugr.es
34-958-243-497
University of Granada
A study conducted at the University of Granada hasdemonstrated that ibuprofen a non-steroidal anti-inflammatory drug (NSAID) has beneficial effects on bone repair after afracture or following bone surgery.
In vitro tests demonstrated that unlike other NSAIDs when a therapeutic dose of ibuprofen is administered, it has no negative effects on the proliferation and synthesis of obsteoblast osteocalcin, a cell which is directly involved in the formation and regeneration of bones.
Osteoblast cells are bone cells that synthesize the bone matrix. Consequently, osteoblasts play a major role in bone development, growth, maintenance and repair.
Positive Results
In an article recently published in the prestigious Journal of Bone and Mineral Metabolism, the University of Granada researchers report the positive effects of ibuprofen on bone repair. The researchers are members of the research group BIO277, which studies the effects of different pharmacological and non-pharmacological therapies on obsteoblast cells.
The primary author of this article, Concepcin Ruiz Rodrguez, a professor at the University of Granada Nursing Department states that "up to date, we had little information on the effects of ibuprofen on osteoblast cells". The University of Granada study demonstrates that a therapeutic dose of ibuprofen (5-25m.) does not inhibit the proliferation and synthesis of osteocalcinin the MG-63 cell line. However, when higher doses are administered (>25 m.) they may activate other cells, which might explain theexpression of membrane markers and the decrease in the phagocytic capacity.
###
Reference: This article is available at: http://www.ncbi.nlm.nih.gov/pubmed/22543821
Contact: Concepcin Ruiz Rodrguez. University of Granada Department of Nursing. Phone Number: +34 958 243 497. E-mail: crr@ugr.es
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-07/uog-asd070312.php
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